When making facial expressions, lines form on your face as muscle under the skin contract. Each smile, frown, or squint you make contributes to the wrinkles that appear on your face. By temporarily relaxing muscles, neuromodulators soften facial creases and undesirable lines that form over time. Left untreated, some of these facial lines may leave you with unintentional worried or angry expressions. After the age of 20, a person produces about 1 percent less collagen in the skin each year. As a result, the skin becomes thinner, more fragile and prone to wrinkles. Neuromodulators such as Botox and Dysport are the best way to prevent permanent wrinkles and folds from forming.